WikiBiomeThe human microbiome encyclopediaAn alphabetical index of interventions in the public WikiBiome knowledge base.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
The Autoimmune Protocol (AIP) diet is an elimination diet that removes foods associated with increased intestinal permeability and autoimmune activation. In Hashimoto's thyroiditis, it targets the gut-thyroid connection by reducing antigenic triggers that drive molecula…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Berberine is an isoquinoline alkaloid from traditional Chinese medicine (Coptis chinensis, Berberis species) that acts as a prebiotic microbiome modulator rather than a direct antimicrobial at gut-relevant concentrations. It is discussed across 16+ sources in the WikiBi…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Breast milk is the most effective single intervention for NEC prevention. Human milk oligosaccharides (HMOs) — the third most abundant component of breast milk — are selectively metabolized by Bifidobacteria, establishing the protective neonatal microbiome. Formula-fed …
Chelation Therapy is discussed across 45 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Curcumin is discussed across 4 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
High dietary fiber intake as a preventive strategy against ovarian cancer. This is the strongest epidemiological evidence for any dietary intervention in OC, with meta-analytic dose-response data from 13 studies and 142,189 participants.
Dietary fiber supplementation (resistant starch, inulin, arabinoxlan oligosaccharides, or whole-food fiber) to shift gut fermentation from proteolytic to saccharolytic, reducing the two key protein-bound uremic toxins (indoxyl sulfate and p-cresyl sulfate) that drive CK…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Moderate-to-vigorous exercise (~90 min/week) as adjunctive therapy alongside antipsychotics. The strongest evidence base of any non-pharmacological intervention for schizophrenia, with meta-analytic support for both psychiatric symptom reduction and metabolic benefit.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Fecal microbiota transplant (FMT) for ASD aims to replace the dysbiotic gut community with a diverse donor microbiome. Open-label results show improvements in both GI symptoms and behavioral measures, but benefits are lost within weeks after cessation.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Glutathione Supplementation is discussed across 32 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Gluten-Free Diet is discussed across 7 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation.
Indole-3-carbinol (I3C) and its metabolite 3,3'-diindolylmethane (DIM) — derived from cruciferous vegetables and also produced by gut bacteria from tryptophan metabolism — as multi-mechanism agents for ovarian cancer. Three independent papers support I3C through distinc…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Early-life supplementation with L. rhamnosus GG (LGG) before 27 days of age reduced the risk of beta-cell autoimmunity in genetically at-risk infants, as demonstrated in the TEDDY study (The Environmental Determinants of Diabetes in the Young).
The combination of lactoferrin + L. rhamnosus GG (LGG) ranked SUCRA 95.7% for lowest NEC rate in a network meta-analysis of 27 RCTs (n=9,501). This intervention exemplifies multiple Karen's Brain primitives operating synergistically.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Low-carbohydrate diets reduce esophageal acid exposure time from 5.1% to 2.5% (P=0.022) by decreasing gastric distension and transient lower esophageal sphincter relaxations (TLESRs). Critically, benefits are independent of weight loss.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
The Mediterranean diet demonstrated broad symptomatic improvement in fibromyalgia across multiple domains in an RCT (n=84), including pain, disability, fatigue, anxiety, and depression at 2 months.
The Mediterranean diet is associated with a 47% reduction in GERD odds (OR=0.53) at the highest adherence level. Multiple complementary mechanisms contribute to symptom relief beyond simple acid suppression.
Adherence to the Alternate Mediterranean Diet (AMED) pattern — high in fiber, polyphenols, omega-3 fatty acids, and plant-based foods — as both a preventive and post-diagnosis survival strategy. This is the only dietary pattern with direct overall survival data in OC.
The Mediterranean diet improves glycemic control and cardiovascular risk in T1D youth while promoting butyrate-producing taxa depleted in T1D, particularly F. prausnitzii. Combination with L. johnsonii N6.2 supplementation has been proposed.
Melatonin is discussed across 7 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Metformin is discussed across 25 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Multi-strain synbiotic supplementation (probiotic + prebiotic) as adjunctive therapy alongside antipsychotics. This is the strongest validated microbiome-targeted intervention for schizophrenia, with both psychiatric symptom improvement and metabolic benefit demonstrate…
N-Acetylcysteine (NAC) is a glutathione precursor and glutamatergic modulator that addresses two key features of ASD pathophysiology: oxidative stress and excitatory-inhibitory imbalance. A pilot RCT demonstrated large effect sizes for irritability reduction.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Omega-3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — are anti-inflammatory polyunsaturated fatty acids that counterbalance the pro-inflammatory effects of omega-6 arachidonic acid. They act through multiple mechanisms: competitive COX-2/5-L…
Plant-based diets shift the gut microbiome from proteolytic to saccharolytic fermentation, reducing production of the uremic toxins indoxyl sulfate (IS) and p-cresyl sulfate (PCS) that accelerate CKD progression. Plant protein has lower bioavailability, which reduces gl…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Multi-strain probiotic supplementation with L. acidophilus, B. longum, and B. bifidum has shown promise in slowing CKD progression through anti-inflammatory mechanisms, though its effect on uremic toxins remains unconfirmed.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Probiotic supplementation targeting the dysbiosis-thyroid axis aims to restore Lactobacillus and Bifidobacterium populations depleted in Hashimoto's thyroiditis, with potential downstream effects on iodine and selenium metabolism.
Probiotic supplementation targeting depleted Bifidobacterium and Lactobacillus in the postpartum period aims to restore gut-brain axis signaling disrupted during the dramatic hormonal shifts following delivery.
Co-administration of multi-strain probiotics (Bifidobacterium, Lactobacillus, Enterococcus, Bacillus cereus) alongside PPI therapy to mitigate PPI-induced gut dysbiosis. This addresses the treatment paradox: PPIs improve esophageal inflammation but worsen gut microbial …
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Resveratrol is discussed across 5 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Selenium supplementation at 200mcg/day reduces TPO antibody titers in Hashimoto's thyroiditis, validated across multiple RCTs. Selenium is the essential cofactor for glutathione peroxidase (GPX) and deiodinase enzymes critical to thyroid function and defense.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Statin Therapy is discussed across 18 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Statins (HMG-CoA reductase inhibitors) are the most prescribed drug class worldwide for cholesterol lowering. In the WikiBiome framework, statins are notable for their microbiome-modulating effects and drug repurposing potential beyond cardiovascular disease — including…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Co-supplementation of vitamin D3 (50,000 IU every 2 weeks) + 4-strain probiotic (L. acidophilus, B. bifidum, L. reuteri, L. fermentum; 8 x 10^9 CFU/day) for 12 weeks, adjunctive to antipsychotics. This is the strongest single-trial result for a microbiome-targeted inter…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Zinc supplementation addresses the functional zinc deficiency in ASD caused by toxic metal displacement at binding sites. Lead, mercury, and cadmium enter cells via calcium channels and displace zinc from critical enzymes and structural proteins (Primitive 3: mis-metall…