Metformin is discussed across 25 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Triangle Evidence#
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Cross-References#
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References 8
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Ilze Elbere, Ineta Kalnina, Ivars Silamikelis et al. (2018). Elbere et al. 2018 — Association of Metformin Administration with Gut Microbiome Dysbiosis in Healthy Volunteers. PLOS ONE.
- 2
Hao Wu, Eduardo Esteve, Valentina Tremaroli et al. (2017). Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine.
- 3
Anna Griffith, Adam Perlman, Tara Karr et al. (2026). Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement Therapy. Frontiers in Endocrinology.
- 4
Elizabeth Varghese, Samson Mathews Samuel, Alena Liskova et al. (2021). Varghese 2021 — Diabetes and Coronavirus (SARS-CoV-2): Molecular Mechanism of Metformin Intervention and the Scientific Basis of Drug Repurposing. PLoS Pathogens.
- 5
Tsushima Y, Nachawi N, Pantalone KM et al. (2024). Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report. Frontiers in Nutrition.
- 6
Thomas Bryrup, Cecilie W. Thomsen, Timo Kern et al. (2019). Bryrup 2019 — Metformin-Induced Changes of the Gut Microbiota in Healthy Young Men: Results of a Non-Blinded, One-Armed Intervention Study. Diabetologia.
- 7
Ying Xia, Ming Sun, Hai Huang et al. (2024). Drug Repurposing for Cancer Therapy. Signal Transduction and Targeted Therapy.
- 8
Wei Ma, Ji Chen, Yuhong Meng et al. (2018). Ma 2018 — Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis. Frontiers in Microbiology.
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- published revision
massive wiki expansion: 149 stubs fixed, 100+ new pages, Rule 15 scan, keystone papers
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semantic integrity pass: boundary fixes, 10 interventions, 31 STOPs, 2 supersessions, keystone revalidation
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