Adherence to the Alternate Mediterranean Diet (AMED) pattern—high in fiber, polyphenols, omega-3 fatty acids, and plant-based foods—as both a preventive and post-diagnosis survival strategy. This is the only dietary pattern with direct overall survival data in OC.
Evidence map2 cited passagesInspect provenance +
Source:
Source:
Evidence#
Prospective Cohort (Chen 2024)#
- Design: Prospective cohort with pre- and post-diagnosis dietary assessment
- Key outcome: High AMED intake: HR = 0.59 (95% CI 0.38-0.90) for overall survival
- Trajectory matters: Decreased AMED intake from pre- to post-diagnosis linked to worse survival; maintaining consistently high AMED associated with benefit
- Source:[1]Association between pre-diagnosis and post-diagnosis Alternate Mediterranean Diet and ovarian cancer survivalChen YH, Bao RH, Liu JC et al. · 2024Open reference 1 ↓
Preclinical Support (AlHilli 2025)#
- High-fat and ketogenic diets accelerated EOC tumor growth in mice, reduced gut diversity, and upregulated polyamine biosynthesis (tumor-promoting pathway)
- Low-fat/high-carbohydrate diet maintained higher diversity and distinct protective taxa
- Source:[2]The effects of dietary fat on gut microbial composition and function in a mouse model of ovarian cancerAlHilli MM, Sangwan N, Myers A et al. · 2025Open reference 2 ↓
Mechanism#
Microbiome diversity preservation: Mediterranean diet maintains microbial alpha-diversity, which is significantly reduced in OC tumor tissue (P=0.0215). SCFA production support: High fiber content feeds depleted butyrate producers. Anti-inflammatory: Polyphenols and omega-3s reduce the inflammatory tumor microenvironment driven by Gram-negative bacteria and LPS.
Polyamine suppression: Avoids the polyamine biosynthesis upregulation seen with high-fat/ketogenic diets. Metal chelation: Polyphenols in Mediterranean diet chelate iron and copper, potentially reducing Fenton chemistry.
Clinical Context#
The trajectory finding is critical: patients who decrease dietary quality after OC diagnosis have worse outcomes. This argues for active dietary counseling as part of OC treatment protocols, not just prevention.
References 2
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Chen YH, Bao RH, Liu JC et al. (2024). Association between pre-diagnosis and post-diagnosis Alternate Mediterranean Diet and ovarian cancer survival. Journal of Translational Medicine.
- 2
AlHilli MM, Sangwan N, Myers A et al. (2025). The effects of dietary fat on gut microbial composition and function in a mouse model of ovarian cancer. Journal of Ovarian Research.
Article network
Mentioned here 1
Pages linking here 1
Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Activity and accepted changes
Accepted researcher context, editorial status, public discussion, and upstream Git revisions are shown together. Pending, declined, and withdrawn proposals remain private.
- published revision
Deepen metal/concept entities + 8 new sources for T1D/schizophrenia
WikiBiome Deploy Bot · +61 −0
Inspect exact Git diff ↗