High dietary fiber intake as a preventive strategy against ovarian cancer. This is the strongest epidemiological evidence for any dietary intervention in OC, with meta-analytic dose-response data from 13 studies and 142,189 participants.
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Source:
Prebiotic effect: Fermentable fiber feeds Coprococcus, Butyricicoccus, Oscillibacter, Fusicatenibacter—all significantly depleted in OC patients (, n=382)
Butyrate production: Butyrate has direct anti-inflammatory and anti-tumor properties; identified as a causal protective factor by Mendelian randomization
Evidence#
Meta-Analysis (Zheng 2018)#
Design: Systematic review and meta-analysis, 13 studies, 5,777 OC cases, 142,189 participants. Primary outcome: Highest vs. lowest fiber intake: RR = 0.78 (95% CI: 0.70-0.88), no heterogeneity. Dose-response: Each 10 g/day increase = 12% reduced OC risk (RR: 0.88).
Source:.[1]Zheng 2018 — Dietary Fiber Intake and Reduced Risk of Ovarian Cancer: A Meta-AnalysisBin Zheng, Hong Shen, Huan Han et al. · 2018Open reference 1 ↓
Mechanism#
Fiber targets the core ecological disruption in OC—SCFA depletion from loss of butyrate-producing genera. Prebiotic effect: Fermentable fiber feeds Coprococcus, Butyricicoccus, Oscillibacter, Fusicatenibacter—all significantly depleted in OC patients (,[2]Characteristics and potential diagnostic value of gut microbiota in ovarian tumor patientsGong W, Jin G, Bao Y et al. · 2025Open reference 2 ↓ n=382).
Butyrate production: Butyrate has direct anti-inflammatory and anti-tumor properties; identified as a causal protective factor by Mendelian randomization.[3]Guo 2025 — Exploring the Causal Associations of the Gut Microbiota and Plasma Metabolites with Ovarian CancerJia Guo, Cheng Wang, Hui Li et al. · 2025Open reference 3 ↓
Estrogen metabolism: Fiber may modulate estrobolome activity by altering the microbial community responsible for beta-glucuronidase production, reducing estrogen recirculation relevant to estrogen-dependent OC.
References 3
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Bin Zheng, Hong Shen, Huan Han et al. (2018). Zheng 2018 — Dietary Fiber Intake and Reduced Risk of Ovarian Cancer: A Meta-Analysis. Nutrition Journal.
- 2
Gong W, Jin G, Bao Y et al. (2025). Characteristics and potential diagnostic value of gut microbiota in ovarian tumor patients. Scientific Reports.
- 3
Jia Guo, Cheng Wang, Hui Li et al. (2025). Guo 2025 — Exploring the Causal Associations of the Gut Microbiota and Plasma Metabolites with Ovarian Cancer. Journal of Ovarian Research.
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