WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Gingipains are the zinc-dependent cysteine proteases that serve as the master virulence factors of porphyromonas gingivalis. Three gingipains exist: RgpA and RgpB (arginine-specific) and Kgp (lysine-specific). They require zinc as a catalytic cofactor, making gingipain …
Alloscardovia is a genus of anaerobic, Gram-positive bacteria in the family Bifidobacteriaceae (phylum Actinobacteria). The primary species is A. omnicolens, which colonizes the human urogenital tract. In the WikiBiome vault, Alloscardovia appears exclusively in endomet…
lead (Pb) has no safe level of exposure. Unlike most dietary metals, lead does not play any known biological role — every atom absorbed represents toxic burden. While environmental lead exposure (paint, soil, air) has decreased dramatically since leaded gasoline phase-o…
Dysmenorrhea -- painful menstruation -- is the most common gynecological complaint, affecting 50-90% of reproductive-age women. It is classified as primary (no identifiable pelvic pathology) or secondary (caused by conditions such as endometriosis, adenomyosis, or fibro…
Fibromyalgia (FM) is a chronic pain syndrome affecting 2-4% of the global population Heidari et al. 2017, characterized by widespread musculoskeletal pain, fatigue, cognitive dysfunction ("fibro fog"), and sleep disturbances. Conventionally attributed to central sensiti…
Functional shielding is the phenomenon in which one microorganism — typically a fungus — physically and immunologically protects a co-resident pathogen from host immune attack, antimicrobial agents, and oxidative stress. The shielding organism's biofilm matrix acts as a…
Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by painful nodules, abscesses, and sinus tracts in apocrine gland-bearing skin (axillae, groin, inframammary folds). Long classified as a purely dermatological condition, emerg…
IL-8 (CXCL8) is the primary neutrophil chemokine — it recruits neutrophils to infection sites and activates their antimicrobial functions (oxidative burst, degranulation, NET formation). In the WikiBiome context, IL-8 is notable for its vulnerability to gingipain degrad…
A functional gastrointestinal disorder affecting 10-15% of the global population, characterized by chronic abdominal pain, bloating, and altered bowel habits (diarrhea-predominant, constipation-predominant, or mixed) without identifiable structural pathology. From a met…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
The Mediterranean diet demonstrated broad symptomatic improvement in fibromyalgia across multiple domains in an RCT (n=84), including pain, disability, fatigue, anxiety, and depression at 2 months.
Periodontitis is a chronic inflammatory disease of the periodontal tissues (gingiva, periodontal ligament, alveolar bone) driven by a dysbiotic polymicrobial biofilm in the subgingival pocket. The keystone pathogen is porphyromonas gingivalis, whose zinc-dependent gingi…
A Gram-negative, obligate anaerobic genus with the keystone pathogen P. gingivalis at its center. Named for its porphyrin (heme) requirement, Porphyromonas is the prototypical periodontal pathogen and one of the most important organisms connecting oral health to systemi…
A Gram-negative obligate anaerobe and keystone pathogen of the oral microbiome that causes chronic periodontitis and is increasingly implicated in systemic diseases including alzheimers disease and cardiovascular disease. P. gingivalis virulence is fundamentally depende…
Fish is the primary dietary source of methylmercury (MeHg) -- a potent neurotoxin that crosses the blood-brain barrier, depletes glutathione, and can increase amyloid-beta production and tau phosphorylation mercury. MeHg is 95-100% absorbed in the intestinal tract. An e…