WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Anxiety disorders are the most prevalent mental health conditions globally, affecting ~280 million people (~4.8% of the world population). They encompass generalized anxiety disorder (GAD), social anxiety, panic disorder, and phobias. In the WikiBiome context, anxiety f…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Bile acids are cholesterol-derived amphipathic molecules synthesized in the liver, secreted into the duodenum, and extensively modified by gut bacteria. The host-microbe co-metabolism of bile acids creates a signaling network with profound effects on lipid metabolism, g…
A Gram-positive, obligate anaerobic genus within the lachnospiraceae family (Firmicutes phylum). Dorea occupies a mixed role in the gut ecosystem -- while it is a core member of the healthy human microbiome, several species are consistently enriched in autoimmune and ne…
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Hungatella hathewayi is a Gram-positive, obligate anaerobic bacterium within the Firmicutes phylum (family Clostridiaceae) that has rapidly emerged as a multi-disease cancer-associated pathobiont. A recently reclassified genus (from Clostridium hathewayi), it is now rec…
An umbrella term for chronic relapsing-remitting inflammatory conditions of the gastrointestinal tract, principally crohns disease (CD; transmural, any GI segment) and ulcerative colitis (UC; mucosal, colon only). Approximately 6 million patients worldwide. IBD represen…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
The only archaeon represented in this wiki -- Methanobrevibacter smithii is the dominant methane-producing microorganism in the human gut, belonging to the domain Archaea rather than Bacteria. As a hydrogenotrophic methanogen, it converts H2 + CO2 into methane (CH4), pl…
Methanobrevibacter smithii is the dominant methanogenic archaeon in the human gut, responsible for consuming hydrogen gas produced by fermentative bacteria and converting it to methane. Despite being an archaeon rather than a bacterium, it represents 0–15% of gut microb…
The second most common neurodegenerative disease, affecting over 10 million people worldwide dorsey 2018 parkinsons incidence meta analysis. Characterized by progressive loss of dopaminergic neurons in the substantia nigra, alpha-synuclein aggregation (Lewy bodies), and…
Live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. In the context of this wiki, probiotics are relevant both as therapeutic agents for metal-related diseases and as mediators of gut metal microbiome interactions. Their …
A Gram-positive obligate anaerobe that has emerged as a pro-inflammatory pathobiont enriched across multiple disease states including crohns disease, depression, and multiple sclerosis. R. gnavus produces a species-specific inflammatory polysaccharide that activates int…
Saccharomyces cerevisiae is a unicellular budding fungus (ascomycete) ubiquitous in fermentation, brewing, bread-making, and increasingly used as a pharmaceutical probiotic (Hatoum et al. 2012). The strain S. boulardii (also called S. cerevisiae var. boulardii) is the m…
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…