WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Bile acids are cholesterol-derived amphipathic molecules synthesized in the liver, secreted into the duodenum, and extensively modified by gut bacteria. The host-microbe co-metabolism of bile acids creates a signaling network with profound effects on lipid metabolism, g…
Bile salt hydrolase (BSH) is the microbial enzyme that deconjugates primary bile acids (taurocholate, glycocholate) by cleaving the amino acid (taurine or glycine) from the steroid core. This is the first and rate-limiting step in microbial bile acid transformation — wi…
A genus of Gram-positive, obligate anaerobic bacteria within the Actinobacteria phylum (family Coriobacteriaceae) that has emerged as a consistent pathobiont enriched in cardiometabolic and autoimmune diseases. C. aerofaciens is the most studied species, with establishe…
Drug repurposing (also called drug repositioning) is the strategy of identifying new therapeutic uses for existing approved drugs. It dramatically accelerates the path from bench to bedside because safety, pharmacokinetics, and manufacturing are already established. In …
Erysipelotrichaceae is a family within the phylum Firmicutes that has drawn increasing attention for its consistent enrichment in metabolic disorders. Members of this family are Gram-positive, obligate anaerobes found throughout the mammalian gastrointestinal tract, whe…
The farnesoid X receptor (FXR), also known as NR1H4, is a nuclear receptor that functions as the primary bile acid sensor in the body. Activated by bile acids — especially chenodeoxycholic acid (CDCA) — FXR regulates bile acid synthesis, cholesterol metabolism, glucose …
Lipid metabolism — the synthesis, transport, and degradation of fats — is profoundly modulated by both the gut microbiome and metal homeostasis. The microbiome influences lipid metabolism through bile acid transformation, SCFA production, TMAO generation, and direct enz…
A Gram-positive, obligate anaerobic genus within the family lachnospiraceae (phylum Firmicutes) that was recently reclassified from Ruminococcus based on phylogenomic evidence. The key species Mediterraneibacter faecis (formerly Ruminococcus gnavus clade relatives) is a…
Mycoplasma is a genus of wall-less bacteria in the class Mollicutes, characterized by the smallest genomes of any self-replicating organisms (~580–1,350 kb). The lack of a cell wall makes them intrinsically resistant to beta-lactam antibiotics and undetectable by Gram s…
A Gram-positive, obligate anaerobic genus that has emerged as one of the most consistently enriched taxa in colorectal cancer. The key pathogenic species P. anaerobius promotes colorectal carcinogenesis through multiple mechanisms including cholesterol biosynthesis indu…
A Gram-positive, obligate anaerobic bacterium within the Firmicutes phylum (family Peptostreptococcaceae) that has emerged as a consistently enriched organism in the colorectal cancer tumor microenvironment. While fusobacterium nucleatum receives the most attention as a…
Statin Therapy is discussed across 18 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.
Statins (HMG-CoA reductase inhibitors) are the most widely prescribed drug class globally, used primarily for cholesterol lowering and cardiovascular risk reduction. Over 200 million people take statins worldwide. Beyond their canonical mechanism of inhibiting cholester…
Statins (HMG-CoA reductase inhibitors) are the most prescribed drug class worldwide for cholesterol lowering. In the WikiBiome framework, statins are notable for their microbiome-modulating effects and drug repurposing potential beyond cardiovascular disease — including…