Statins

Microbiome Effects#

Rosuvastatin alters gut microbiome composition during lipid-lowering therapy.^{[1]Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in VivoYinhui Liu, Xiaobo Song, Huimin Zhou et al. · 2018Open reference 1 ↓} Simvastatin promotes Lactobacillus expansion and cholesterol metabolism in CRC context.^{[2]Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatmentXiaoliang Xie, Wenjing Wang, Haiming Zhang et al. · 2025Open reference 2 ↓} Statin users show distinct gut microbiome profiles compared to non-users.

Drug Repurposing#

BV/vaginolysin: Statins deplete membrane cholesterol → reduce vaginolysin (cholesterol-dependent cytolysin) binding → attenuate Gardnerella virulence.^{[3]Abdelmaksoud 2017 — Association between Statin Use, the Vaginal Microbiome, and Gardnerella vaginalis Vaginolysin-Mediated CytotoxicityAbdelmaksoud AA, Girerd PH, Garcia EM et al. · 2017Open reference 3 ↓} Parkinson's: Statin use associated with altered gut microbiome and potential neuroprotection.^{[4]Mertsalmi 2023 -- Statins and Gut Microbiome in Parkinson's DiseaseEero Mertsalmi, Velma T E Aho, Pedro A B Pereira et al. · 2023Open reference 4 ↓}

Cancer: Statins show chemopreventive effects in breast and colorectal cancer.^{[5]The role of statins in the regulation of breast and colorectal cancer and future directionsDang Y, Zhang Y, Wang Z · 2025Open reference 5 ↓} Preterm birth: Statin repurposing for preterm delivery prevention.^{[6]Whitaker 2021 — Could Statins Be a Novel Therapeutic for the Prevention of Preterm Delivery? Evidence from an Animal Model and Phase II Feasibility TrialEleanor Whitaker · 2021Open reference 6 ↓}