Molecular Mechanisms of Cellular Injury and Role of Toxic Heavy Metals in Chronic Kidney Disease
Manish Mishra, Larry Nichols, Aditi A. Dave, Elizabeth H. Pittman, John P. Cheek, Anasalea J.V. Caroland, Purva Lotwala, James Drummond, Christy C. Bridges
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Citation record
- Year
- 2022
- Journal
- International Journal of Molecular Sciences
- WikiBiome key
mishra-2022-molecular-mechanisms-heavy-metals-ckd
Maps distinct metal-specific mechanisms of kidney injury for arsenic (ROS/MAPK/NF-kB activation), cadmium (electron transport chain disruption, ER stress, 10→25% CKD risk), and mercury (mitochondrial depolarization, cytoskeletal damage)—establishing these metals as distinct nephrotoxins with separate mechanistic signatures. WikiBiome depends on this evidence to explain why CKD populations accumulate toxic metals, enabling characterization of the reciprocal metal-kidney-disease pathway across signature layers.
Criteria met: 2 · 3 · 4Used in 24 visible records
metalCadmium→diseaseChronic Kidney Disease→diseaseGastric Cancer→metalIron→metalMercury→mechanismDNA Damage in Metal Carcinogenesis→mechanismAlpha-Klotho→mechanismAutophagy→mechanismChelation Therapy→defenseCysteine→defenseFerritin→defenseFerroportin→mechanismFerroptosis→defenseGlutathione (GSH)→defenseHepcidin→mechanismImmune Balance→defenseMetal-Driven Inflammation→mechanismLipid Peroxidation→mechanismMetal Chelation Therapy→mechanismMitochondrial Dysfunction→mechanismNF-kB Signaling Pathway→mechanismOxidative Stress→defenseReactive Oxygen Species (ROS)→mechanismTGF-beta (Transforming Growth Factor Beta)→Connect the evidence
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