Effects of Heavy Metals on Gut Barrier Integrity and Gut Microbiota
Sweta Ghosh, Syam P. Nukavarpu, Venkatakrishna Rao Jala
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- Year
- 2024
- Journal
- Microbiota and Host
- WikiBiome key
ghosh-2023-heavy-metals-gut-barrier-integrity
Comprehensively maps metal-specific mechanisms of tight junction disruption (arsenic: paracellular transport; lead: claudin/occludin loss; mercury: permeability increase; cadmium: E-cadherin downregulation) and identifies metal-susceptible vs. metal-resistant microbiota species. WikiBiome depends on this evidence to explain barrier collapse as the critical intermediate step connecting metal burden to systemic dysbiosis—showing how microbial metabolites and probiotic species can counteract metal-induced permeability.
Criteria met: 1 · 2 · 3 · 4Used in 24 visible records
microbeAkkermansia muciniphila→diseaseAlzheimer's Disease→metalArsenic→diseaseAutism Spectrum Disorder→metalCadmium→metalChromium→diseaseChronic Kidney Disease→diseaseErectile Dysfunction→microbeFaecalibacterium prausnitzii→microbeFaecalibacterium→metalLead→metalMercury→metalNickel→microbeOscillospiraceae→diseaseType 2 Diabetes→diseaseUlcerative Colitis→defenseCysteine→mechanismDysbiosis→mechanismEndotoxemia→mechanismFarnesoid X Receptor (FXR)→mechanismGut Barrier Dysfunction→mechanismGut-Metal-Microbiome Interactions→mechanismHeavy Metals→mechanismImmune Balance→Connect the evidence
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