WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Metabolomics is the comprehensive measurement of small-molecule metabolites (<1,500 Da) in a biological sample -- the functional readout of what the genome, transcriptome, and microbiome are actually doing. While genomics tells you what organisms are present and metagen…
Measurable indicators of biological state, exposure, or disease. In the metallomics context, biomarkers span three interconnected domains: metal biomarkers (quantifying exposure and body burden), microbiome biomarkers (reflecting microbial community disruption), and met…
Cardiovascular disease (CVD) -- encompassing atherosclerosis, coronary artery disease, hypertension, myocardial infarction, heart failure, and stroke -- is the leading cause of death globally. The gut-heart axis has emerged as a central paradigm linking microbial metabo…
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer death. Over 90% of cases are sporadic, driven by a complex interplay between genetic predisposition, dietary habits, gut microbiome composition, and environmental ex…
Depression is the most prevalent mental health disorder globally, affecting over 280 million people zhu 2025 microbiota gut brain axis depression review, and one of the most metal-sensitive conditions in this wiki. It sits at the convergence of nearly every pathway cata…
Endometriosis is a chronic estrogen-dependent inflammatory condition affecting approximately 10% of reproductive-age women, characterized by the growth of endometrial-like tissue outside the uterus colonetti 2023 gut vaginal microbiota endometriosis meta analysis. The c…
Gordonibacter is a genus of Gram-positive, strictly anaerobic gut bacteria within the phylum Actinobacteria. It is recognized as a key participant in polyphenol metabolism, producing bioactive metabolites including equol (from dietary isoflavones) and urolithins (from e…
Metallomics is the systematic study of metals and metalloids in a biological system. The metallome is the set of metal and metalloid species present in a defined organism, tissue, cell, fluid, or microbial community; metallomics is the measurement and interpretation of …
The use of gut microbiome composition, microbial metabolites, or microbial products as diagnostic, prognostic, or monitoring tools for disease. Unlike traditional clinical biomarkers, microbial biomarkers capture the functional state of the host-microbiome ecosystem and…
Microbiome-derived metabolites are small molecules made, consumed, or chemically transformed through activity in the gut microbiome and other host-associated communities. They connect community function to host biology, but the phrase covers several kinds of provenance:…
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, with a global prevalence of approximately 2.8 million attfield 2022 immunology ms nature review. The conventional framing centers on genetic susceptibility (HLA-DRB115:0…
Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal emergency in premature infants, affecting 5-12% of very low birth weight neonates (<1500 g) with mortality rates of 20-30%. Characterized by intestinal inflammation, necrosis, and perforation…
Pancreatic cancer is the fifth leading cause of cancer death in Western nations, with rising incidence globally. Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of cases. Five-year survival remains approximately 12%, owing to late-stage diagnosis, aggressi…
The second most common neurodegenerative disease, affecting over 10 million people worldwide dorsey 2018 parkinsons incidence meta analysis. Characterized by progressive loss of dopaminergic neurons in the substantia nigra, alpha-synuclein aggregation (Lewy bodies), and…
Urea is the substrate of urease. In the microbial systems covered by WikiBiome, urease hydrolyzes urea to ammonia and bicarbonate; those products can supply microbial nitrogen and help neutralize acidic environments maier 2019 nickel microbial pathogenesis. At a glance,…