Metal Ion Acquisition in Staphylococcus aureus: Overcoming Nutritional Immunity
James E. Cassat, Eric P. Skaar
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- Year
- 2012
- Journal
- Seminars in Immunopathology
- WikiBiome key
cassat-2012-metal-acquisition-staphylococcus-aureus
Maps the complete metal acquisition arsenal of Staphylococcus aureus and the nutritional immunity systems the host deploys to counter each—transforming WikiBiome's understanding of how calprotectin-mediated manganese/zinc sequestration drives both pathogenic persistence and dysbiotic inflammation. This mechanistic completeness is foundational to modeling metal-dependent pathogenesis across wound, respiratory, and systemic infections.
Criteria met: 1 · 3 · 4Used in 24 visible records
microbeBacillus→metalCobalt→metalIron→metalManganese→microbeMycobacterium tuberculosis→metalNickel→microbeSalmonella→microbeStaphylococcus aureus→microbeStaphylococcus→metalZinc→mechanismCambialistic Enzymes→mechanismCatalase→defenseInter-Kingdom Metal Shielding→mechanismLabile Metal Pool→mechanismMatrix Metalloproteases (MMPs)→defenseMetal-Dependent Virulence→defenseMetal Homeostasis→mechanismMetallochaperone→defenseMicrobial Metallomics→defenseNutritional Immunity (Metal Sequestration)→mechanismOxidative Stress→defensePathogen Metal Acquisition Systems→defenseSiderophores and Metallophores→defenseSiderophores→Connect the evidence
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