WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Endotoxemia is the presence of bacterial endotoxin (lipopolysaccharide, LPS) in the bloodstream. Metabolic endotoxemia — chronic, low-grade LPS translocation from the gut — is a central mechanism linking dysbiosis to systemic disease across dozens of conditions in this …
Aspirin (acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) that irreversibly inhibits cyclooxygenase (COX) enzymes, suppressing prostaglandin synthesis. While widely used as an antiplatelet and anti-inflammatory agent, aspirin carries significant i…
Atherosclerosis is a chronic inflammatory disease of arterial walls characterized by lipid-laden plaque formation, endothelial dysfunction, and progressive vascular occlusion. It is the pathological substrate underlying coronary artery disease, stroke, and peripheral ar…
Bacteremia is the presence of viable bacteria in the bloodstream. In the WikiBiome framework, bacteremia results from bacterial translocation across compromised barriers — the gut epithelium (→ portal bacteremia) or the oral mucosa (→ systemic bacteremia during dental p…
Cardiovascular disease (CVD) -- encompassing atherosclerosis, coronary artery disease, hypertension, myocardial infarction, heart failure, and stroke -- is the leading cause of death globally. The gut-heart axis has emerged as a central paradigm linking microbial metabo…
A progressive loss of kidney function affecting approximately 850 million people worldwide (10–14% of adults), causing 1.2 million deaths annually. CKD is unique among diseases in this wiki because it occupies both sides of the metal-disease equation: heavy metals (Cd, …
Cirrhosis is end-stage liver fibrosis characterized by nodular regeneration, portal hypertension, and progressive hepatic failure. The gut-liver axis is central: portal venous blood delivers gut-derived LPS, bacterial DNA, and viable bacteria directly to the liver, and …
Endothelial dysfunction is the impairment of the vascular endothelium's ability to produce nitric oxide (NO), regulate vascular tone, and prevent thrombosis. It is the earliest detectable stage of atherosclerosis and the mechanistic link between gut dysbiosis, systemic …
The gut-prostate axis describes the bidirectional communication between the gut microbiome and the prostate gland. Gut-derived microbial metabolites, inflammatory mediators, and immune signals influence prostatic health, while prostatic disease states alter systemic inf…
Leptin is an adipokine (hormone produced by adipose tissue) that signals satiety to the hypothalamus — suppressing appetite and increasing energy expenditure. Leptin resistance (elevated leptin with impaired signaling) is a hallmark of obesity, paralleling insulin resis…
Lipopolysaccharide (LPS), also called endotoxin, is a major structural component of the outer membrane of Gram-negative bacteria. When released into circulation through a compromised gut barrier, LPS triggers potent inflammatory signaling via Toll-like receptor 4 (TLR4)…
Post-acute sequelae of SARS-CoV-2 infection (PASC), affecting an estimated 10-30% of COVID-19 survivors (WHO and CDC post-acute surveillance estimates) with symptoms persisting 12 weeks. Characterized by fatigue, cognitive dysfunction ("brain fog"), exercise intolerance…
Major depressive disorder (MDD) is a psychiatric condition characterized by persistent depressed mood, anhedonia, and cognitive/somatic symptoms. In the WikiBiome framework, MDD is a paradigm case for the gut brain axis: gut dysbiosis drives systemic inflammation and ne…
Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), encompasses a spectrum from simple hepatic steatosis to metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), fibrosis…
Systemic inflammation is the state in which inflammatory mediators — IL-6, TNF-alpha, CRP, IL-1beta — circulate throughout the body rather than remaining confined to a local injury site. In the WikiBiome framework, systemic inflammation is the final common pathway throu…
Tight junctions are the multiprotein complexes that seal the paracellular space between intestinal epithelial cells, forming the physical barrier that separates the gut lumen (with its ~10^13 bacteria, LPS, and dietary antigens) from the underlying lamina propria and sy…
Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance and progressive beta-cell dysfunction, affecting over 500 million people worldwide (IDF Diabetes Atlas 2021). The conventional framing centers on caloric excess and sedentary behavior. The …