Search: “NSAID”

Ranked matches across titles, topics, categories, and article introductions.

8 records in this view

Clinical cautions1 sources

STOP: NSAIDs in Chronic Kidney Disease

This knowledge-base record is being expanded from WikiBiome’s evidence graph.

Mechanisms5 sources

Arachidonic Acid

Arachidonic acid (AA) is a 20-carbon omega-6 polyunsaturated fatty acid (20:4n-6) that serves as the primary substrate for prostaglandin and leukotriene synthesis via COX-2 and 5-LOX pathways. It is the dominant pro-inflammatory lipid mediator — and its balance with ant…

Mechanisms3 sources

Aspirin

Aspirin (acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) that irreversibly inhibits cyclooxygenase (COX) enzymes, suppressing prostaglandin synthesis. While widely used as an antiplatelet and anti-inflammatory agent, aspirin carries significant i…

A generic membrane-associated two-subunit enzyme model appears separately from a bent chain and a five-membered-ring token.

Mechanisms6 sources

COX-2 (Cyclooxygenase-2)

Cyclooxygenase-2 (COX-2) is the inducible enzyme that converts arachidonic acid to prostaglandin H₂ — the precursor of prostaglandin E₂ (PGE₂), prostacyclin, and thromboxane. Unlike COX-1 (constitutive, homeostatic), COX-2 is transcriptionally induced by nf kappa b duri…

A closed capsule, a six-well screening plate with one sphere per well, and a folded target-like form with an empty pocket appear separately.

Mechanisms5 sources

Drug Repurposing

Drug repurposing (also called drug repositioning) is the strategy of identifying new therapeutic uses for existing approved drugs. It dramatically accelerates the path from bench to bedside because safety, pharmacokinetics, and manufacturing are already established. In …

An opened stomach with visible folds appears beside a layered gastric-wall model containing one clean crater limited above the deep muscular layers.

Diseases6 sources

Gastric Ulcer

A breach in the gastric mucosal lining extending through the muscularis mucosae, most commonly caused by helicobacter pylori infection or chronic NSAID use. Gastric ulceration represents a critical node in the upper GI disease continuum, linking gerd, chronic gastritis,…

A generic NLRP3 sensor-context form is separated from an eight-subunit circular complex model and a generic whole-cell cutaway with an intact membrane.

Mechanisms7 sources

NLRP3 Inflammasome

The NLRP3 inflammasome is a host innate-immune signaling complex that connects cellular danger signals to caspase-1 activation. In the canonical pathway represented in WikiBiome's evidence vault, caspase-1 processes the inflammatory cytokines IL-1beta and IL-18 and clea…

Mechanisms5 sources

Pharmacomicrobiomics

Pharmacomicrobiomics is the study of bidirectional interactions between drugs and the microbiome. The gut microbiome is not a passive bystander in pharmacology -- it actively metabolizes drugs, alters their bioavailability, and modulates therapeutic efficacy. Conversely…