ZIP8 A391T Crohn's Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation
Yang JC, Zhao M, Chernikova D, Arias-Jayo N, Zhou Y, Situ J, Chang C, Liang F, Lagishetty V, Jacobs JP
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- Year
- 2024
- Journal
- Digestive Diseases and Sciences
- WikiBiome key
yang-2024-zip8-a391t-crohns-metal-dyshomeostasis-microbiome
Shows that the Crohn's-linked ZIP8 A391T variant produces colonic metal ion dyshomeostasis — specifically disrupted zinc and manganese handling — that reshapes the microbiome and inflammatory state. Direct genetic evidence that metal transporters sit upstream of IBD microbiome composition and a mechanistic linchpin for WikiBiome's Crohn's signature.
Criteria met: 1 · 2 · 3Used in 19 visible records
microbeAkkermansia muciniphila→microbeBacteroides fragilis→microbeBacteroides vulgatus→metalCopper→diseaseCrohn's Disease→diseaseInflammatory Bowel Disease (IBD)→microbeLactobacillus→metalManganese→diseaseUlcerative Colitis→metalZinc→mechanismDysbiosis→defenseDyshomeostasis→mechanismGut-Metal-Microbiome Interactions→defenseMetal-Driven Inflammation→stopSTOP: Broad-Spectrum Antibiotics for Crohn's Disease→stopSTOP: Iron Supplementation for Crohn's Disease→stopSTOP: Iron Supplementation (Oral) for IBD/Crohn's Disease→stopSTOP: Zinc Supplementation in H. pylori Infection→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
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