WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
The Autoimmune Protocol (AIP) diet is an elimination diet that removes foods associated with increased intestinal permeability and autoimmune activation. In Hashimoto's thyroiditis, it targets the gut-thyroid connection by reducing antigenic triggers that drive molecula…
Erysipelotrichaceae is a family within the phylum Firmicutes that has drawn increasing attention for its consistent enrichment in metabolic disorders. Members of this family are Gram-positive, obligate anaerobes found throughout the mammalian gastrointestinal tract, whe…
The gut-thyroid axis describes the bidirectional communication between the gut microbiome and the thyroid gland. The thyroid regulates metabolism, energy homeostasis, and immune function -- and the microbiome influences thyroid physiology at every level: mineral absorpt…
Hashimoto's thyroiditis (HT) is the most common autoimmune disease globally and the leading cause of hypothyroidism. Chronic lymphocytic infiltration of the thyroid gland progressively destroys follicular architecture, reducing thyroid hormone output. Prevalence is 5-10…
A Gram-positive, obligate anaerobic genus within the Firmicutes phylum (family Oscillospiraceae or Ruminococcaceae depending on classification) that possesses a unique metabolic capability: butyrate production from lysine fermentation rather than from dietary fiber. Thi…
Lachnoclostridium is a genus of obligate anaerobic, Gram-positive bacteria in the lachnospiraceae family. It is a butyrate-producing commensal with emerging clinical significance as a treatment response biomarker and diagnostic marker.
Molecular mimicry occurs when microbial antigens share structural similarity with host proteins, triggering cross-reactive immune responses that attack host tissue. It is a primary mechanism linking infections and dysbiosis to autoimmune disease — the immune system corr…
Probiotic supplementation targeting the dysbiosis-thyroid axis aims to restore Lactobacillus and Bifidobacterium populations depleted in Hashimoto's thyroiditis, with potential downstream effects on iodine and selenium metabolism.
Selenium supplementation at 200mcg/day reduces TPO antibody titers in Hashimoto's thyroiditis, validated across multiple RCTs. Selenium is the essential cofactor for glutathione peroxidase (GPX) and deiodinase enzymes critical to thyroid function and defense.
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan.
Autoimmune thyroid diseases (AITDs) -- hashimotos thyroiditis and graves disease -- are the most common organ-specific autoimmune conditions, affecting 5-10% of the global population. The thyroid gland sits at a remarkable intersection of metal biology and immune regula…
A Gram-positive, facultatively anaerobic genus within the class Erysipelotrichia (phylum Firmicutes) that has become one of the most frequently identified taxa in gut-brain and gut-immune Mendelian randomization studies. Turicibacter sanguinis, the type species, possess…
Vitamin B12 (cobalamin) is an essential cobalt-containing cofactor required for homocysteine metabolism, methylation reactions, and neurological function. Its core corrin ring chelates a cobalt ion, placing B12 at the intersection of metallomics and microbial ecology. C…
Vitamin D (calciferol; active form: calcitriol/1,25(OH)₂D₃) is a secosteroid hormone with profound immunomodulatory effects. The vitamin D receptor (VDR) is expressed on virtually all immune cells, and vitamin D deficiency is epidemiologically linked to autoimmune disea…