WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Periodontitis is a chronic inflammatory disease of the periodontal tissues (gingiva, periodontal ligament, alveolar bone) driven by a dysbiotic polymicrobial biofilm in the subgingival pocket. The keystone pathogen is porphyromonas gingivalis, whose zinc-dependent gingi…
Bacteremia is the presence of viable bacteria in the bloodstream. In the WikiBiome framework, bacteremia results from bacterial translocation across compromised barriers — the gut epithelium (→ portal bacteremia) or the oral mucosa (→ systemic bacteremia during dental p…
Breast cancer is the most common cancer in women worldwide, with approximately 2.3 million new cases annually. While genetic, hormonal, and lifestyle factors are well-established risk determinants, the metallomic dimension reveals a consistent pattern of trace element d…
Cerebral palsy (CP) is the most common motor disability in childhood, affecting 2-3 per 1,000 live births allen 2021 multi organ dysfunction cerebral palsy. Characterized by non-progressive disturbances in movement and posture arising from injury to the developing brain…
Cortisol is the primary glucocorticoid stress hormone, produced by the adrenal cortex under HPA (hypothalamic-pituitary-adrenal) axis control. In the WikiBiome framework, cortisol is the molecular bridge between psychological stress and microbiome disruption — it direct…
Dialister is a genus of Gram-negative, obligate anaerobic bacteria within the family Veillonellaceae that represents one of the strongest protective associations in gut-brain-axis research. Dialister depletion is a consistent and independent biomarker of depression, anx…
Functional shielding is the phenomenon in which one microorganism — typically a fungus — physically and immunologically protects a co-resident pathogen from host immune attack, antimicrobial agents, and oxidative stress. The shielding organism's biofilm matrix acts as a…
A Gram-negative obligate anaerobe that has emerged as a major pathogen in colorectal cancer (CRC) and inflammatory bowel disease. F. nucleatum is significantly enriched in CRC tissue and tumors compared to healthy mucosa, making it one of the strongest microbe-cancer as…
Gingipains are the zinc-dependent cysteine proteases that serve as the master virulence factors of porphyromonas gingivalis. Three gingipains exist: RgpA and RgpB (arginine-specific) and Kgp (lysine-specific). They require zinc as a catalytic cofactor, making gingipain …
A Gram-negative obligate anaerobe and keystone pathogen of the oral microbiome that causes chronic periodontitis and is increasingly implicated in systemic diseases including alzheimers disease and cardiovascular disease. P. gingivalis virulence is fundamentally depende…
Zinc deficiency is a consistent finding in breast cancer, and Zn plays key roles in immunity (T cell differentiation), p53 activation, and SOD cofactor function. Yet supplementation data are limited, and in the Sister Study, zinc showed a dose-related positive associati…