WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
The Th17/Treg balance is the immunological equilibrium between pro-inflammatory T helper 17 (Th17) cells and anti-inflammatory regulatory T (Treg) cells. This balance is the master switch between immune tolerance and autoimmune/inflammatory pathology — and the gut micro…
Autoimmunity occurs when the immune system attacks the body's own tissues. What has emerged over the past two decades is that the gut microbiome is not merely associated with autoimmune disease -- it is a mechanistic driver of immune tolerance breakdown. Metals add a se…
Debaryomyces is a genus of ascomycetous fungi, with D. hansenii being the most clinically relevant species, that represents a prominent opportunistic pathobiont enriched in inflammatory bowel disease, particularly crohns disease. Unlike many commensal fungi, Debaryomyce…
Graves' disease (GD) is an autoimmune thyroid disorder characterized by TSH receptor antibodies (TRAb) that stimulate the thyroid gland, causing hyperthyroidism kahaly 2022 graves disease targeted therapy review. It is the most common cause of hyperthyroidism, with conc…
Hashimoto's thyroiditis (HT) is the most common autoimmune disease globally and the leading cause of hypothyroidism. Chronic lymphocytic infiltration of the thyroid gland progressively destroys follicular architecture, reducing thyroid hormone output. Prevalence is 5-10…
Interleukin-17 (primarily IL-17A and IL-17F) is the signature cytokine of Th17 cells. At physiological levels, IL-17 maintains mucosal barrier defense by recruiting neutrophils and inducing antimicrobial peptide production. At pathological levels (Th17/Treg imbalance), …
The immune system is not a monolith but a dynamic equilibrium between pro-inflammatory effector responses (Th1, Th2, Th17) and anti-inflammatory regulatory responses (Treg, IL-10, TGF-beta). Metals and the microbiome are two of the most potent environmental modulators o…
Interleukin-22 (IL-22) is an immune signaling protein that helps coordinate host responses at epithelial surfaces. In the gut evidence represented by WikiBiome, group 3 innate lymphoid cells (ILC3s) are a prominent source, while Th17-associated responses can also includ…
Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by keratinocyte hyperproliferation, resulting in well-demarcated erythematous plaques with silvery scales. Affecting approximately 2-3% of the global population, psoriasis is now understood …
A severe neuropsychiatric disorder affecting approximately 1% of the global population, characterized by positive symptoms (hallucinations, delusions), negative symptoms (anhedonia, social withdrawal, flat affect), and cognitive deficits. Life expectancy is reduced by 1…
Streptococcus thermophilus is a Gram-positive, facultative anaerobic coccus that is the primary probiotic species used in commercial yogurt fermentation and thermophilic dairy fermentation worldwide. Distinct from pathogenic Streptococcus species, S. thermophilus produc…
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.