Parasutterella

Succinate Production#

P. excrementihominis is a succinate producer rather than a classical SCFA (Butyrate/propionate) producer. Succinate serves as both a metabolic intermediate and an immune signaling molecule, activating succinate receptor 1 (SUCNR1/GPR91) on dendritic cells and macrophages. This positions Parasutterella as a modulator of innate immune responses through its metabolic output.

Bile Acid Metabolism#

Implicated in bile acid transformation pathways, potentially influencing the enterohepatic circulation of bile acids. Its role in bile acid metabolism connects to broader effects on cholesterol handling and lipid homeostasis.

Lipid Associations#

MR analyses link Parasutterella to higher ApoB and LDL-cholesterol levels,^{[1]Causality of the gut microbiome and atherosclerosis-related lipids: a bidirectional Mendelian Randomization studyDa Teng, Wenjuan Jia, Wenlong Wang et al. · 2024Open reference 1 ↓} suggesting a causal role in lipid metabolism. Decreased following ketogenic diet intervention in CRC models,^{[2]Ketogenic diet suppresses colorectal cancer through reshaping gut microbiota and modulating the intestinal FXR/NF-kB signaling pathwayQinhan Gao, Yuwen Liu, Fayu Su et al. · 2026Open reference 2 ↓} consistent with dietary fat composition influencing its abundance.

Cardiovascular Disease#

MR evidence identifies Parasutterella as protective against coronary artery disease (OR=0.936).^{[3]Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysisXiao-Ce Dai, Yi Yu, Si-Yu Zhou et al. · 2024Open reference 3 ↓} This protective CVD association exists despite its positive correlation with LDL-C, suggesting complex mechanisms beyond simple lipid effects.

Endometriosis#

Enriched in mouse models of Endometriosis, identified as one of ten characteristic bacteria with high LDA scores in endometriotic mice.^{[4]Ni 2020 — Fecal Metabolomics and Gut Microbiota Correlation in Endometriosis MiceZhexin Ni, Shuai Sun, Yanli Bi et al. · 2020Open reference 4 ↓}

Also enriched alongside Bifidobacterium in endometriosis mouse models.^{[5]Yuan 2018 — Endometriosis Induces Gut Microbiota Alterations in MiceMing Yuan, Dong Li, Zhe Zhang et al. · 2018Open reference 5 ↓}

Autoimmune Thyroiditis#

Significantly increased after 4 weeks of gluten-free diet in autoimmune thyroiditis patients (p=0.008), alongside increases in Desulfobacterota and Proteobacteria.^{[6]Rodziewicz et al. 2024 — Gluten-Free Diet Alters the Gut Microbiome in Women with Autoimmune ThyroiditisRodziewicz A, Szewczyk A, Bryl E · 2024Open reference 6 ↓}

Its increase on GFD connects to emerging roles in Tryptophan Metabolism metabolism and gut-immune interactions.

IBD#

Altered in Inflammatory Bowel Disease (IBD), with context-dependent changes in Crohn's disease versus ulcerative colitis. Its Proteobacteria lineage places it in a phylum that is generally expanded in IBD-associated Dysbiosis.

Dietary Responsiveness#

Parasutterella is notably responsive to dietary interventions. Decreased by Lactobacillus supplementation.^{[7]Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatmentXiaoliang Xie, Wenjing Wang, Haiming Zhang et al. · 2025Open reference 7 ↓} Decreased by ketogenic diet.^{[2]Ketogenic diet suppresses colorectal cancer through reshaping gut microbiota and modulating the intestinal FXR/NF-kB signaling pathwayQinhan Gao, Yuwen Liu, Fayu Su et al. · 2026Open reference 2 ↓}

Increased by gluten-free diet.^{[6]Rodziewicz et al. 2024 — Gluten-Free Diet Alters the Gut Microbiome in Women with Autoimmune ThyroiditisRodziewicz A, Szewczyk A, Bryl E · 2024Open reference 6 ↓}