Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder
Tizabi Y, Bennani S, El Kouhen N, Getachew B, Aschner M
Share & cite
Links open in a new tab.
Citation record
- Year
- 2023
- Journal
- Biomolecules
- WikiBiome key
tizabi-2023-lead-gut-microbiota-asd
Links lead exposure to autism-spectrum gut dysbiosis via specific taxa shifts — Faecalibacterium depletion, Lactobacillus loss, Desulfovibrio enrichment — consistent with the broader ASD microbial signature. Anchors lead as a metal driver of the autism signature and contributes to the cross-condition pattern in which Pb recurs across neurodevelopmental and neurodegenerative conditions.
Criteria met: 1 · 2 · 3 · 4Used in 14 visible records
diseaseAutism Spectrum Disorder→metalCalcium→microbeCoprococcus→microbeFirmicutes (Bacillota)→metalLead→metalZinc→mechanismDevelopmental Metal Vulnerability: Critical Windows of Susceptibility→mechanismDysbiosis→mechanismGut-Brain Axis→mechanismGut-Metal-Microbiome Interactions→mechanismHeavy Metal Neurotoxicity→mechanismMetal Chelation Therapy→mechanismMicroglia→mechanismNeuroinflammation→Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Activity and accepted changes
Accepted researcher context, editorial status, public discussion, and upstream Git revisions are shown together. Pending, declined, and withdrawn proposals remain private.
No public collaboration activity has been recorded for this page yet.