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Metals in the pathogenesis of type 2 diabetes

Abdul Rehman Khan, Fazli Rabbi Awan

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Year
2014
Journal
Journal of Diabetes and Metabolic Disorders
WikiBiome key
khan-2014-metals-type2-diabetes
Why this source matters

Establishes that type 2 diabetes is characterized by zinc depletion (via urinary loss and ZnT8 transporter dysfunction) and iron overload (elevated ferritin driving insulin resistance), while toxic metals (lead, nickel, cadmium, arsenic) directly impair insulin signaling and glucose metabolism. WikiBiome depends on this evidence to explain why metal-dysregulated microbiota (depleted in zinc-dependent bacteria) cannot restore insulin sensitivity—linking nutritional immunity failure to dysbiotic metabolic incompetence.

Criteria met: 2 · 3 · 4

Used in 13 visible records

metalChromium→diseaseChronic Kidney Disease→metalCopper→metalIron→metalMagnesium→metalManganese→metalNickel→diseaseType 2 Diabetes→metalZinc→mechanismInsulin Resistance→stopSTOP: Iron Supplementation for Type 2 Diabetes-Associated Anemia→stopSTOP: Iron Supplementation for PCOS→analysisMetal-Disease Matrix: A Cross-Source Synthesis→
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