Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk
Guevara-Ramirez P, Tamayo-Trujillo R, Cadena-Ullauri S, Ruiz-Pozo V, Paz-Cruz E, Annunziata G, Verde L, Frias-Toral E, Simancas-Racines D, Zambrano AK
Share & cite
Links open in a new tab.
Citation record
- Year
- 2024
- Journal
- Food and Agricultural Immunology
- WikiBiome key
guevara-ramirez-2024-dietary-heavy-metals-neurodegeneration
Links dietary metal exposure (mercury, cadmium, lead, arsenic in foods) to neurodegenerative disease mechanisms through metal-specific pathways: mercury disrupts glutamate transport, cadmium blocks calcium channels, arsenic dysregulates dopamine, chromium generates ROS, lead crosses the BBB. WikiBiome depends on this evidence to explain how food-borne metal burden—not environmental exposure alone—drives proteinopathy and why dietary interventions (phytochemicals, chelation) can interrupt metal-driven neurodegeneration.
Criteria met: 1 · 2 · 4Used in 11 visible records
diseaseAlzheimer's Disease→metalChromium→diseaseDepression→metalLead→metalMercury→metalNickel→mechanismBlood-Brain Barrier→mechanismEDTA→mechanismHeavy Metals→mechanismMitochondrial Dysfunction→mechanismNeurodegeneration and Metals→Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Activity and accepted changes
Accepted researcher context, editorial status, public discussion, and upstream Git revisions are shown together. Pending, declined, and withdrawn proposals remain private.
No public collaboration activity has been recorded for this page yet.