Role of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or Not?
Aquino NB, Sevigny MB, Sabangan J, Louie MC
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- Year
- 2012
- Journal
- Journal of Environmental Science and Health Part C - Environmental Carcinogenesis and Ecotoxicology Reviews
- WikiBiome key
aquino-2012-cadmium-nickel-metalloestrogens
Establishes cadmium and nickel as metalloestrogens with distinct mechanistic signatures: cadmium binds ERα with affinity near estradiol, activating classical estrogen target genes; nickel induces histone deacetylation and tumor suppressor methylation without competing for estradiol binding. WikiBiome depends on this evidence to explain how metal burden drives estrogen-dependent dysbiosis (estrobolome expansion) in endometriosis and hormonally-sensitive cancers—linking metallomics to the estrobolome pathway.
Criteria met: 2 · 3 · 4Used in 16 visible records
diseaseBreast Cancer→metalCadmium→diseaseEndometriosis→diseaseFemale Infertility→metalNickel→diseasePolycystic Ovary Syndrome→mechanismAcidic Microenvironment→mechanismAromatase→mechanismEndocrine Disruption→mechanismMetalloestrogen→mechanismMetalloestrogens→mechanismMis-Metallation→stopSTOP: Calcium Supplementation with Cadmium Exposure→stopSTOP: Iron Supplementation for PCOS→stopSTOP: Standard (Unselected) Probiotics for Endometriosis→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
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