Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer's Disease: A Review of Recent Evidence from Mechanistic Studies
Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez, Khalid M. Khan
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- Year
- 2025
- Journal
- Journal of Xenobiotics
- WikiBiome key
ahmed-2025-metals-alzheimers-mechanistic-review
Comprehensively maps metal-specific mechanisms (arsenic: tau phosphorylation via GSK3-beta/ERK; manganese: autophagy impairment; lead/cadmium: blood-brain barrier disruption) converging on Alzheimer's disease pathology across 45 mechanistic studies. WikiBiome depends on this evidence to explain how distinct metal burdens select for divergent neurodegenerative trajectories—establishing metal-specific toxicology as deterministic of proteinopathy type rather than a generic oxidative insult.
Criteria met: 2 · 3 · 4Used in 18 visible records
diseaseAlzheimer's Disease→metalCalcium→metalLead→metalManganese→metalNickel→diseaseParkinson's Disease→mechanismAmyloid-Beta Aggregation→mechanismAmyloid-Beta→mechanismAutophagy→defenseDyshomeostasis→mechanismImmune Balance→defenseMetal-Driven Inflammation→mechanismMicroglia→mechanismNeurodegeneration and Metals→mechanismNeuroinflammation→mechanismNF-kB Signaling Pathway→mechanismTau Phosphorylation→stopSTOP: Iron Supplementation for Alzheimer's Disease→Connect the evidence
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