WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to signature.
Anxiety disorders are the most prevalent mental health conditions globally, affecting ~280 million people (~4.8% of the world population). They encompass generalized anxiety disorder (GAD), social anxiety, panic disorder, and phobias. In the WikiBiome context, anxiety f…
A neurodevelopmental condition affecting approximately 1 in 36 children (US CDC 2023 estimate), characterized by differences in social communication, restricted interests, and repetitive behaviors. From a metallomics perspective, ASD presents a compelling convergence of…
Celiac disease is a chronic autoimmune condition triggered by dietary gluten (gliadin proteins from wheat, barley, and rye) in genetically susceptible individuals (HLA-DQ2/DQ8, carried by ~30-40% of Europeans but penetrant in only ~1% of carriers). Gluten exposure cause…
A progressive loss of kidney function affecting approximately 850 million people worldwide (10–14% of adults), causing 1.2 million deaths annually. CKD is unique among diseases in this wiki because it occupies both sides of the metal-disease equation: heavy metals (Cd, …
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer death. Over 90% of cases are sporadic, driven by a complex interplay between genetic predisposition, dietary habits, gut microbiome composition, and environmental ex…
Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures, affecting ~50 million people worldwide. Approximately 30% of patients have drug-resistant epilepsy -- a population where microbiome-targeted interventions (particularly the ketog…
Erectile dysfunction (ED) affects 30-50% of men aged 40-70 Feldman et al. 1994, with prevalence increasing with age. Conventionally understood as a vascular and/or neurogenic disorder, ED is now recognized as a condition with a significant gut microbiome component -- th…
Affects approximately 48 million women worldwide (WHO global infertility prevalence estimates). From a microbiome-metallomics perspective, female infertility sits at the intersection of the estrobolome (microbial estrogen metabolism), heavy metal reproductive toxicity (…
Sustained elevation of systemic blood pressure, affecting an estimated 1.3 billion adults worldwide and the leading modifiable risk factor for cardiovascular disease, stroke, and chronic kidney disease. The gut microbiome-blood pressure axis has emerged as a major resea…
Post-acute sequelae of SARS-CoV-2 infection (PASC), affecting an estimated 10-30% of COVID-19 survivors (WHO and CDC post-acute surveillance estimates) with symptoms persisting 12 weeks. Characterized by fatigue, cognitive dysfunction ("brain fog"), exercise intolerance…
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system, with a global prevalence of approximately 2.8 million attfield 2022 immunology ms nature review. The conventional framing centers on genetic susceptibility (HLA-DRB115:0…
A chronic metabolic condition affecting over 1 billion people globally, characterized by excess adipose tissue accumulation, systemic low-grade inflammation, and gut microbiome disruption pendergrass 2026 heavy metals obesity epidemic. From a metallomics perspective, ob…
Premenstrual Dysphoric Disorder (PMDD) affects 3-8% of menstruating individuals Epperson et al. 2012, causing severe mood disturbances, irritability, anxiety, and physical symptoms during the luteal phase of the menstrual cycle. Distinguished from premenstrual syndrome …
A severe neuropsychiatric disorder affecting approximately 1% of the global population, characterized by positive symptoms (hallucinations, delusions), negative symptoms (anhedonia, social withdrawal, flat affect), and cognitive deficits. Life expectancy is reduced by 1…
Type 1 diabetes is an autoimmune disease in which immune-mediated destruction of insulin-producing beta cells in the pancreatic islets of Langerhans leads to lifelong insulin dependence. T1D is fundamentally distinct from type 2 diabetes, which is characterized by insul…
Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance and progressive beta-cell dysfunction, affecting over 500 million people worldwide (IDF Diabetes Atlas 2021). The conventional framing centers on caloric excess and sedentary behavior. The …