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Heavy Metals Exposure and Alzheimer's Disease and Related Dementias

Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK

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Year
2020
Journal
Journal of Alzheimer's Disease
WikiBiome key
bakulski-2020-heavy-metals-alzheimers-dementias
Why this source matters

Synthesizes epidemiological evidence linking lead (lifetime cumulative exposure), mercury (organic and inorganic forms), cadmium, and arsenic to Alzheimer's disease and related dementias through multiple pathways: direct neurotoxicity, calcium channel disruption, and epigenetic silencing. Critical for WikiBiome because it establishes metal exposure assessment methodology (bone lead vs. blood lead, biomarker selection) essential for accurate metallomics phenotyping across neurodegenerative disease signatures.

Criteria met: 2 · 3 · 4

Used in 12 visible records

diseaseAlzheimer's Disease→metalCadmium→metalCalcium→metalLead→metalManganese→metalMercury→diseaseParkinson's Disease→mechanismAmyloid-Beta→mechanismNeurodegeneration and Metals→mechanismTau Phosphorylation→stopSTOP: Iron Supplementation for Alzheimer's Disease→analysisMetal-Disease Matrix: A Cross-Source Synthesis→
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