WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Hyperandrogenism -- the clinical or biochemical excess of androgens (testosterone, androstenedione, DHEA-S) -- is a defining feature of polycystic ovary syndrome (PCOS), affecting 60-80% of women with the condition. It manifests as hirsutism, acne, androgenic alopecia, …
Aromatase (CYP19A1) is the cytochrome P450 enzyme that catalyzes the final and rate-limiting step of estrogen biosynthesis — the conversion of androgens (testosterone, androstenedione) to estrogens (estradiol, estrone). It is expressed in the ovaries, placenta, adipose …
Endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with hormone synthesis, secretion, transport, binding, action, or elimination. The classical EDC list -- BPA, phthalates, dioxins, PCBs, pesticides -- is well established. What WikiBiome adds …
Estrogen recirculation is the recycling loop by which conjugated estrogens excreted in bile are deconjugated by gut bacterial beta glucuronidase, reabsorbed across the intestinal epithelium, and returned to systemic circulation uzuner 2023 bidirectional relationship end…
The gut-prostate axis describes the bidirectional communication between the gut microbiome and the prostate gland. Gut-derived microbial metabolites, inflammatory mediators, and immune signals influence prostatic health, while prostatic disease states alter systemic inf…
The gut-testis axis describes the bidirectional communication between the gut microbiome and the male reproductive system. Gut-derived microbial metabolites, immune signals, and systemic inflammatory mediators influence testicular function, testosterone biosynthesis, an…
A metabolic-endocrine disorder affecting 6-20% of reproductive-age women worldwide, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary morphology (Rotterdam criteria) barrea 2019 mediterranean diet pcos. PCOS is the leading cause of anovulatory i…
The primary androgen in human biology, testosterone sits at a critical intersection in WikiBiome's framework: it is both regulated by the gut microbiome and disrupted by heavy metals, making it a node where environmental metal exposure, microbial ecology, and endocrine …