Ursodeoxycholic acid is a hydrophilic secondary bile acid used therapeutically for primary biliary cholangitis (PBC), gallstone dissolution, and cholestatic liver disease. It is also a microbial metabolite—gut bacteria (7α/β-hydroxysteroid dehydrogenases) convert chenodeoxycholic acid to UDCA. Emerging evidence supports drug repurposing for CRC chemoprevention and ASD.
Evidence map3 cited passagesInspect provenance +
CRC: UDCA reduces colonic epithelial cell proliferation and apoptosis resistance; counteracts the pro-carcinogenic effects of deoxycholic acid (DCA).
ASD: UDCA + propionic acid modulation improves behavioral outcomes in autism animal models.
Colitis-associated CRC: Modulates Treg function in colitis-cancer models.
Drug Repurposing#
CRC: UDCA reduces colonic epithelial cell proliferation and apoptosis resistance; counteracts the pro-carcinogenic effects of deoxycholic acid (DCA).[1]Rezen et al. 2022 — The Role of Bile Acids in CarcinogenesisRezen T, Rozman D, Kovacs T et al. · 2022Open reference 1 ↓
ASD: UDCA + Propionic Acid modulation improves behavioral outcomes in autism animal models.[2]Karakas 2023 — Lowering Propionic Acid Levels by Regulating Gut Microbiota with Ursodeoxycholic Acid Appears to Regress Autism Symptoms: An Animal StudyLevent Karakas, Volkan Solmaz, Erman Bascioglu et al. · 2023Open reference 2 ↓ Colitis-associated CRC: Modulates Treg function in colitis-cancer models.[3]Protective Role of Fecal Microbiota Transplantation on Colitis and Colitis-Associated Colon Cancer in Mice Is Associated With Treg CellsZitao Wang, Wenjie Hua, Chen Li et al. · 2019Open reference 3 ↓
Cross-References#
- Bile Acid Metabolism—UDCA as secondary bile acid
- Bile Salt Hydrolase (BSH)—upstream microbial enzyme
- Colorectal Cancer—CRC chemopreventive potential
- Propionic Acid—co-modulator in ASD models
References 3
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Rezen T, Rozman D, Kovacs T et al. (2022). Rezen et al. 2022 — The Role of Bile Acids in Carcinogenesis. Cellular and Molecular Life Sciences.
- 2
Levent Karakas, Volkan Solmaz, Erman Bascioglu et al. (2023). Karakas 2023 — Lowering Propionic Acid Levels by Regulating Gut Microbiota with Ursodeoxycholic Acid Appears to Regress Autism Symptoms: An Animal Study. Journal of Health Sciences and Medicine.
- 3
Zitao Wang, Wenjie Hua, Chen Li et al. (2019). Protective Role of Fecal Microbiota Transplantation on Colitis and Colitis-Associated Colon Cancer in Mice Is Associated With Treg Cells. Frontiers in Microbiology.
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