Synbiotics

Clinical Evidence#

ASD: Synbiotic improved GI symptoms, behavior, and anxiety; restored Dialister abundance.^{[1]Mitchell 2024 — Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following Synbiotics vs Gut-Directed HypnotherapyLeanne K. Mitchell, Helen S. Heussler, Christopher J. Burgess et al. · 2024Open reference 1 ↓} Schizophrenia: Synbiotic improved metabolic syndrome parameters in schizophrenia RCT.^{[2]Effects of Synbiotic Supplementation on the Components of Metabolic Syndrome in Patients with Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled TrialBasafa-Roodi P, Jazayeri S, Hadi F et al. · 2024Open reference 2 ↓} Hypothyroidism: Synbiotic improved thyroid function alongside levothyroxine.^{[3]The Effect of Synbiotic Supplementation on Hypothyroidism: A Randomized Double-Blind Placebo Controlled Clinical TrialRamezani M, Reisian M, Sajadi Hezaveh Z · 2023Open reference 3 ↓}

Breast cancer: Synbiotic during chemotherapy supported immune function.^{[4]The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancerKhazaei Y, Basi A, Fernandez ML et al. · 2023Open reference 4 ↓} Crohn's disease: Synbiotic (B. longum + inulin-FOS) improved clinical and histological outcomes in RCT.^{[5]Clinical Trial: The Microbiological and Immunological Effects of Synbiotic Consumption - A Randomised Double-Blind Placebo-Controlled Study in Active Crohn's DiseaseSteed H, Macfarlane GT, Blackett KL et al. · 2010Open reference 5 ↓} Pancreatic cancer: Perioperative synbiotic improved immunomodulation post-resection.^{[6]Synergistic immunomodulatory effect of synbiotics pre- and postoperative resection of pancreatic ductal adenocarcinoma: a randomized controlled studySara Maher, Hesham A. Elmeligy, Tarek Aboushousha et al. · 2024Open reference 6 ↓}