WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Defensins are small (29–45 amino acid) cationic antimicrobial peptides that form the first line of chemical defense at mucosal surfaces. Alpha-defensins (HD5, HD6) are produced by Paneth cells in the small intestinal crypts; beta-defensins (hBD1-4) are produced by epith…
A pathotype of escherichia coli that adheres to and invades intestinal epithelial cells, survives and replicates within macrophages, and is strongly associated with ileal Crohn's disease. Unlike classical diarrheagenic E. coli pathotypes (EPEC, ETEC, EHEC), AIEC does no…
Innate immunity is the body's first-line, non-specific defense against pathogens — comprising physical barriers (epithelium, mucus), antimicrobial molecules (calprotectin, lactoferrin, defensins), pattern recognition receptors (TLRs, NOD-like receptors), and phagocytic …