Costafrolaz 2026 — Asymmetric Envelope Surface Disposition of Secreted Protein YjbI Controls Bimodal Antibiotic Susceptibilities in C. crescentus
Jordan Costafrolaz, Laurence Degeorges, Gael Panis, Simon-Ulysse Vallet, Manuel Velasco Gomariz, Fernando Teixeira Pinto Meireles, Matteo Dal Peraro, Kathrin S Frohlich, Patrick H Viollier
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- Year
- 2026
- Journal
- The EMBO Journal
- WikiBiome key
costafrolaz-2026-yjbi-envelope-zinc-stress-antibiotic-caulobacter
Reveals that zinc stress doesn't merely inhibit cytoplasmic enzymes but triggers outer membrane proteome remodeling, exposing normally-impermeable antibiotic binding sites (TonB-dependent receptor BugA) that confer vancomycin and bacitracin susceptibility. WikiBiome uses this evidence to explain why zinc-restricted environments (nutritional immunity response, dysbiotic low-zinc states) become selective for zinc-efflux-pump-expressing pathogens while paradoxically increasing antibiotic vulnerability—a mechanism enabling zinc-based ecological engineering.
Criteria met: 1 · 4 · 5Used in 4 visible records
microbeCaulobacter→metalZinc→mechanismOuter Membrane→mechanismsRNA (Small Regulatory RNA)→Connect the evidence
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