WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter with a remarkable split life: ~90-95% of body serotonin is produced in the gut by enterochromaffin (EC) cells, not in the brain. This peripheral serotonin regulates intestinal motility, secretion, vis…
The serotonin-estrogen axis describes the bidirectional relationship between estrogen signaling and serotonin (5-HT) neurotransmission — a neuroendocrine interface that is profoundly modulated by the gut microbiome. Estrogen regulates serotonin synthesis (via tryptophan…
Tryptamine is a microbial decarboxylation product of tryptophan, produced by bacterial tryptophan decarboxylase (found in ruminococcus gnavus, Clostridium sporogenes, and others). It is a serotonin receptor agonist (particularly 5-HT4) that stimulates gut motility and f…