Campylobacter

Metal Dependencies#

Iron: Campylobacter possesses multiple iron uptake systems including siderophore receptors and heme/hemoglobin acquisition proteins. Iron restriction impairs colonization.^{[1]Role of Nickel in Microbial PathogenesisRobert J. Maier, Stéphane L. Benoit · 2019Open reference 1 ↓}

Nickel: NiFe Hydrogenase is essential for C. jejuni colonization of the chicken cecum and human gut—hydrogen oxidation provides a colonization advantage in the microaerobic niche.^{[1]Role of Nickel in Microbial PathogenesisRobert J. Maier, Stéphane L. Benoit · 2019Open reference 1 ↓}

cobalt (Co)-selection: The AcrAB-TolC efflux pump confers resistance to both fluoroquinolones AND metals, making environmental metal exposure a driver of antibiotic-resistant Campylobacter.^{[2]Understanding the Development of Environmental Resistance Among Microbes: A ReviewSrivastava J, Chandra H, Singh N et al. · 2016Open reference 2 ↓[3]Baker-Austin 2006 — Co-selection of Antibiotic and Metal ResistanceBaker-Austin C, Wright MS, Stepanauskas R et al. · 2006Open reference 3 ↓}

Disease Associations#

Heart failure: Part of gut Dysbiosis in heart failure via Mendelian randomization.^{[4]Effects of Gut Microbiota and Metabolites on Heart Failure and Its Risk Factors: A Two-Sample Mendelian Randomization StudyQiang Luo, Yilan Hu, Xin Chen et al. · 2022Open reference 4 ↓} IBD: Campylobacter concisus enriched in IBD; may act as pathobiont in inflamed mucosa.^{[5]Wang 2024 — Integrated 16S rRNA sequencing and metagenomics insights into microbial dysbiosis and distinct virulence factors in inflammatory bowel diseaseHaijing Wang, Yuanjun Wang, Libin Yang et al. · 2024Open reference 5 ↓}

Prostatitis: Detected in chronic prostatitis microbiome.^{[6]Vocca 2025 — Probiotics in the Management of Chronic Bacterial Prostatitis: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom ReliefCristina Vocca, Diana Marisol Abrego-Guandique, Erika Cione et al. · 2025Open reference 6 ↓}